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Related Experiment Videos

Intermediate filaments and their associated proteins: multiple dynamic personalities

M K Houseweart1, D W Cleveland

  • 1Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla 92093, USA.

Current Opinion in Cell Biology
|March 4, 1998
PubMed
Summary

Intermediate filaments provide a crucial flexible scaffold for cell structure, confirmed by mouse and human genetics. A new protein family links these filaments to actin and microtubules, organizing the cytoplasm.

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Area of Science:

  • Cell Biology
  • Cytoskeletal Dynamics
  • Molecular Cell Biology

Background:

  • Intermediate filaments are key cytoskeletal components.
  • Their role in cytoplasmic organization is under investigation.

Purpose of the Study:

  • To elucidate the structural role of intermediate filaments in cellular organization.
  • To identify proteins involved in intermediate filament-mediated scaffolding.

Main Methods:

  • Comparative genetics (mouse and human).
  • Cellular and molecular biology techniques.

Main Results:

  • Intermediate filaments form an essential flexible scaffold for cytoplasmic structure.
  • A novel family of intermediate-filament-associated proteins was identified.

Related Experiment Videos

  • These proteins create cross-bridges connecting intermediate filaments to actin and microtubules.

    • Conclusions:

    • Intermediate filaments are vital for maintaining cytoplasmic architecture.
    • Newly discovered proteins play a critical role in integrating the cytoskeleton.