Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Well-differentiated thyroid carcinomas: p53 mutation status and microvessel density

J D Goldenberg1, L G Portugal, B L Wenig

  • 1Department of Otolaryngology-Head and Neck Surgery, Eye and Ear Infirmary, University of Illinois at Chicago, 60612, USA.

Head & Neck
|March 4, 1998
PubMed
Summary

This study found that while microvessel density (MVD) increased in thyroid tumors, it did not predict clinical outcomes. P53 gene mutations also did not serve as a prognostic indicator for well-differentiated thyroid carcinoma.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[The evolution and current status of transoral robotic surgery with single-port system].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2025
Same author

[Transoral robotic surgery with single-port robot system for tongue base cancer: preliminary experience].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2025
Same author

[Single-port transoral robotic surgery for laryngeal and pharyngeal benign lesions].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2025
Same author

[Transoral robotic surgery with single-port robot system for tongue base cancer].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2025
Same author

[A comprehensive review and future prospects of biobanking pathogenic microorganisms causing human infections in China].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·2024
Same author

[Effect of recombinant human thrombin for hemostasis in liver resection: a randomized controlled phase Ⅲ clinical trial].

Zhonghua yi xue za zhi·2023

Area of Science:

  • Oncology
  • Pathology
  • Molecular Biology

Background:

  • Established risk-stratification schemes for well-differentiated thyroid carcinoma exist, incorporating factors like age, sex, tumor extent, size, and metastasis.
  • Clinical outcomes in low-risk patients have raised questions regarding the optimal aggressiveness of initial surgical intervention.
  • The prognostic significance of biologic tumor markers, p53 gene mutation and CD34 microvessel density (MVD), requires further investigation in well-differentiated thyroid tumors.

Purpose of the Study:

  • To determine the prognostic significance of p53 gene mutation and CD34 microvessel density (MVD) in well-differentiated thyroid carcinoma.
  • To evaluate the correlation between these biologic markers and clinical behavior or pathological features.
  • To assess their utility as independent prognosticators in thyroid cancer management.

Related Experiment Videos

Main Methods:

  • Selection of 38 patients with well-differentiated thyroid carcinomas from the University of Illinois Tumor Registry.
  • Average clinical follow-up of 10 years for all selected patients.
  • Immunohistochemistry performed on paraffin-embedded tumor specimens to identify p53 gene mutations and quantify CD34 microvessel density (MVD).

Main Results:

  • Microvessel density (MVD) counts were significantly increased in thyroid tumor tissue compared to surrounding normal tissue.
  • No significant correlation was found between elevated MVD and tumor histology or recurrence rates.
  • A trend suggested higher MVD counts in patients initially presenting with metastatic lymphadenopathy. P53 mutation expression was observed in 28% of cases, with no correlation to histology, sex, recurrence, or survival.

Conclusions:

  • The study supports the concept of tumor neovascularization but did not establish a correlation between MVD and the clinical behavior or pathological features of well-differentiated thyroid carcinoma.
  • P53 mutation status was found not to be an independent prognosticator of tumor behavior in the studied thyroid lesions.
  • Further research may be needed to identify reliable prognostic markers for optimizing treatment strategies in well-differentiated thyroid carcinoma.