Multiple cavernous angiomas after high-dose whole-brain radiation therapy

Modern neuroimaging techniques have led to increased identification of angiographically occult cerebral angiomatous malformations. Cavernous angiomas or cavernomas account for approximately 16% of all cerebrovascular malformations. Little is reported about the etiology or risk for acquiring these lesions. This report suggests a possible association between acquired intracranial vascular malformations and long-term survivors after craniospinal external beam radiation therapy indicating that greater understanding of the cerebral vascular system's response to injury may provide insight into the evolution and progression of these lesions.