Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The platelet thrombin receptor and postoperative bleeding

V A Ferraris1, S P Ferraris, A Singh

  • 1Division of Cardiothoracic Surgery, Albany Medical College, New York, USA.

The Annals of Thoracic Surgery
|March 4, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of the modulatory influence of food additive-garam masala on hepatic detoxication system.

Indian journal of experimental biology·1992
Same author

Cutaneous toxicity of sodium lauryl sulphate, nickel, and their combination in guinea pigs: biochemical and histopathological observations.

Bulletin of environmental contamination and toxicology·1992
Same author

RNase X2, a pistil-specific ribonuclease from Petunia inflata, shares sequence similarity with solanaceous S proteins.

Plant molecular biology·1992
Same author

Dermal toxicity of paraphenylenediamine.

Biomedical and environmental sciences : BES·1992
Same author

Modulation of bilayer structures derived from diacetylenic phosphocholines containing oxygen linker beta to diacetylene.

Chemistry and physics of lipids·1992
Same author

The familial occurrence of Parkinson's disease. Lack of evidence for maternal inheritance.

Archives of neurology·1992

Cardiopulmonary bypass (CPB) reduces platelet thrombin receptor function, leading to postoperative bleeding. Targeting this receptor dysfunction may reduce transfusion needs and improve patient outcomes.

Area of Science:

  • Cardiovascular Surgery
  • Hematology
  • Platelet Physiology

Background:

  • Cardiopulmonary bypass (CPB) may desensitize platelet thrombin receptors.
  • This desensitization could cause postoperative platelet dysfunction and bleeding.

Purpose of the Study:

  • To investigate changes in platelet thrombin receptor function during CPB.
  • To correlate these changes with postoperative bleeding.

Main Methods:

  • Studied 79 patients undergoing CPB.
  • Measured platelet function (aggregation, activation, adhesion) using aggregometry and flow cytometry.
  • Assessed platelet-white cell interactions and surface markers.

Main Results:

  • TRAP-induced platelet activation significantly reduced post-CPB.

Related Experiment Videos

  • Reduced TRAP response correlated with increased need for blood transfusion.
  • Other activating agents showed normal responses by 24 hours post-CPB.

    • Conclusions:

    • CPB impairs platelet activation, aggregation, and leukocyte adhesion via TRAP.
    • Diminished thrombin receptor responsiveness is linked to excessive bleeding.
    • A potential second thrombin receptor may be protected during CPB, suggesting a therapeutic target.