Radiologic-pathologic correlation from the Armed Forces Institute of Pathology. Lymphangiomyomatosis

The radiologic patterns caused by interstitial lung disease evoke a long list of differential diagnostic possibilities. Though the problem may at first seem insoluble, subdivision into conditions that spare the pulmonary architecture, as opposed to those that lead to an end-stage "honeycomb lung", and consideration of the clinical findings will frequently narrow down the list. Occasionally, key associated findings such as pleural effusion, pneumothorax, and systemic involvement of many organs will help rule out inappropriate diagnoses. Lymphangiomyomatosis is a rare cause of "honeycomb lung" that may result in a very specific combination of radiologic and clinical findings.