Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bacterial corneal ulcer: a multivariate study

A G Wang1, C C Wu, J H Liu

  • 1Department of Opthalmology Veterans General Hospital-Taipei, National Yang-Ming University, Taiwan, Republic of China.

Ophthalmologica. Journal International D'Ophtalmologie. International Journal of Ophthalmology. Zeitschrift Fur Augenheilkunde
|March 5, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Clinical efficacy of arthroscopic limited excision of flexor hallucis longus tendon sheath combined with open technique of posterior ankle joint capsule for hallucal ganglion cyst deriving from ankle joint].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2025
Same author

[Analysis of the effect of all-inside endoscopic procedure through two portals combined with double-hemisection Achilles tendon lengthening for Achilles tendon contracture].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2024
Same author

[Analysis of gene characteristics and core genome characteristics of carbapenem-resistant Enterobacter cloacae in rural residents of Weifang City, Shandong Province].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·2024
Same author

[Posterior arthroscopic subtalar arthrodesis for symptomatic adult talocalcaneal coalition].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2023
Same author

[Progress and thinking of minimally invasive technique in the treatment of chronic Achilles tendon rupture].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2022
Same author

[Arthroscopic treatment of acute closed noninsertional rupture of Achilles tendon].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2022

This study on bacterial corneal ulcers found common pathogens like Pseudomonas aeruginosa and Staphylococcus. Contact lens use and prior herpes simplex keratitis were significant risk factors for specific bacterial infections.

Area of Science:

  • Ophthalmology
  • Microbiology
  • Epidemiology

Background:

  • Bacterial corneal ulcers are a significant cause of visual impairment.
  • Understanding the causative pathogens and associated risk factors is crucial for effective treatment and prevention.

Purpose of the Study:

  • To identify the common microbiological causes of bacterial keratitis.
  • To determine the risk factors associated with specific pathogens.
  • To evaluate the in vitro drug sensitivity of isolated microorganisms.

Main Methods:

  • Retrospective clinicomicrobiological review of 314 patients.
  • Multivariate statistical analysis using logistic regression.
  • Identification of pathogens through microbial cultures.
  • Drug sensitivity testing.

Related Experiment Videos

Main Results:

  • 134 (42.7%) of patients had positive cultures.
  • Most frequent pathogens included Pseudomonas aeruginosa, staphylococci, and Acinetobacter spp.
  • Contact lens use linked to P. aeruginosa (OR 8.16).
  • Previous herpes simplex keratitis linked to Streptococcus spp. (OR 18.2).
  • Acinetobacter spp. associated with burns/lagophthalmos (OR 13.1/26.2).
  • Staphylococcus aureus associated with trauma and younger age.
  • Nonpseudomonal gram-negative bacilli associated with older age.
  • Vancomycin and ceftazidime showed highest effectiveness.

Conclusions:

  • Specific risk factors are associated with particular bacterial pathogens in corneal ulcers.
  • Contact lens wear, prior herpetic keratitis, ocular surface compromise, trauma, and age are important considerations.
  • Vancomycin and ceftazidime are effective in vitro against common bacterial isolates.