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Incidental focal acantholytic dyskeratosis
1Department of Pathology, University of Texas--Houston Medical School, 77030, USA.
Journal of the American Academy of Dermatology
|March 5, 1998
Summary
Focal acantholytic dyskeratosis (FAD) is a histologic pattern found incidentally in various skin lesions. This study identified associated lesions, including nevi, scars, and seborrheic keratosis, highlighting its presence in both lesion and adjacent skin.
Area of Science:
- Dermatopathology
- Histopathology
- Oncology
Background:
- Focal acantholytic dyskeratosis (FAD) is a distinct histological pattern.
- Characterized by suprabasilar clefts, acantholytic/dyskeratotic cells, and hyperkeratosis/parakeratosis.
- Often observed as an incidental finding in diverse skin lesions.
Purpose of the Study:
- To identify specific skin lesions associated with incidental FAD.
- To understand the distribution of FAD within or adjacent to these lesions.
Main Methods:
- Retrospective evaluation of eight skin specimens with incidental FAD.
- Comprehensive review of published literature on lesions exhibiting incidental FAD.
Main Results:
- Incidental FAD occurred in nevi with architectural disorder, scars, ruptured follicles, and seborrheic keratosis.
- FAD was found within the lesion (3 cases) or in adjacent 'clinically normal-appearing' skin (5 cases).
- Eight patients ranged from 29 to 53 years; 21 additional cases were reported in the literature.
Conclusions:
- Incidental FAD is associated with a broad spectrum of benign and malignant epithelial, fibrohistiocytic, inflammatory, melanocytic, and miscellaneous lesions.
- The condition can manifest within the primary lesion or in the immediately adjacent epithelium.
- The etiology of this clinically benign yet microscopically notable finding requires further investigation.