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Corticosteroid therapy does not alter the threshold for contraction-induced injury in dystrophic (mdx) mouse
1Respiratory Division, Royal Victoria Hospital, Montreal, Quebec, Canada.
Muscle & Nerve
|March 5, 1998
Abstract:
The effects of methylprednisolone therapy on the susceptibility of dystrophin-deficient myofibers to contraction-induced injury were evaluated in the mdx mouse diaphragm model of Duchenne dystrophy. Mdx myofibers were abnormally vulnerable to injury induced by high-stress eccentric contractions. However, methylprednisolone therapy did not significantly alter the degree of contraction-induced injury. These data suggest that beneficial effects of corticosteroid therapy in Duchenne dystrophy are unlikely to be related to a change in the threshold for contraction-induced myofiber damage.