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(3H)morphine localization in myenteric plexus

I M Diab, R J Dinerstein, M Watanabe

    Science (New York, N.Y.)
    |August 20, 1976
    PubMed
    Summary
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    Morphine preferentially binds to satellite cells in the myenteric plexus, not large neurons. Norepinephrine nerve fibers interact with these satellite cells, suggesting a novel pathway for opioid action.

    Area of Science:

    • Neuroscience
    • Gastroenterology
    • Pharmacology

    Background:

    • The myenteric plexus is a complex network of neurons and glial cells within the gastrointestinal tract.
    • Satellite cells are glial cells that support neurons in the enteric nervous system.
    • The precise interactions and drug targets within the myenteric plexus are not fully elucidated.

    Purpose of the Study:

    • To investigate the binding sites of morphine within the myenteric plexus.
    • To identify the cellular targets of opioid analgesics in the gut.
    • To explore the neurochemical environment surrounding myenteric plexus cells.

    Main Methods:

    • Autoradiography using 3H-labeled morphine to visualize drug binding.
    • Microfluorometry to analyze the chemical composition of nerve fibers.

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  • Histological examination of the myenteric plexus and surrounding tissues.

    • Main Results:

    • Morphine selectively binds to satellite cells, not large neurons, in the myenteric plexus.
    • Nerve fibers containing norepinephrine were observed to directly contact these satellite cells.
    • Serotonin-containing cells were found occasionally outside the main myenteric plexus on longitudinal muscle.

    Conclusions:

    • Satellite cells represent a potential primary target for morphine in the myenteric plexus.
    • The interaction between noradrenergic nerve fibers and satellite cells may play a role in opioid signaling.
    • This study reveals a previously unrecognized cellular mechanism for opioid action in the gut.