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Thermodynamics in biochemical engineering
U von Stockar1, L A van der Wielen
1Institut de génie chimique, Swiss Federal Institute of Technology, Lausanne, Switzerland.
Journal of Biotechnology
|March 6, 1998
Summary
Thermodynamics is crucial for biotechnology but is often overlooked. Applying thermodynamic principles can lead to more rational and efficient bioprocess development, moving away from empirical methods.
Area of Science:
- Biotechnology
- Chemical Thermodynamics
- Bioprocess Engineering
Background:
- Equilibrium aspects in biotechnology and their underlying thermodynamic theory have been underemphasized.
- Current bioprocess design and development often rely on empirical methods.
- There is a need for increased systematic application of thermodynamic principles in biotechnology.
Purpose of the Study:
- To provide an overview of thermodynamic aspects in biotechnology.
- To identify key research needs in the field.
- To encourage a more rigorous thermodynamic description for bioprocess development.
Main Methods:
- Utilized the structure of an advanced course on Process Integration in Biotechnology.
- Reviewed the current state of thermodynamic application in bioprocesses.
- Identified gaps and future research directions.
Main Results:
- Highlighted the limited attention given to equilibrium thermodynamics in biotechnology.
- Emphasized the empirical nature of current bioprocess development.
- Underscored the necessity of a systematic thermodynamic approach.
Conclusions:
- A rigorous thermodynamic description is essential for rational, efficient, and rapid bioprocess development.
- Further research is needed to establish a strong scientific basis for bioprocess design using thermodynamics.
- Integrating thermodynamic principles can significantly advance the field of biotechnology.