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Related Experiment Videos

Calcium antagonists and atherosclerosis

M Schachter1

  • 1Department of Clinical Pharmacology, Imperial College School of Medicine at St. Mary's, London, UK. M.Schachter@ic.ac.uk

International Journal of Cardiology
|March 6, 1998
PubMed
Summary
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Calcium channel blockers (CCBs) show potential in slowing atherosclerosis by affecting vascular smooth muscle cells and lipoproteins. Clinical trials suggest anti-atherosclerotic effects in patients, though further research is needed to confirm their clinical significance.

Area of Science:

  • Cardiovascular Pharmacology
  • Atherosclerosis Research

Background:

  • Calcium channel blockers (CCBs) possess properties that may inhibit key processes in atherosclerosis development.
  • These properties include effects on vascular smooth muscle cells, lipoprotein metabolism, and endothelial function.

Purpose of the Study:

  • To review the potential anti-atherosclerotic effects of CCBs.
  • To summarize outcomes of clinical trials investigating CCBs in human atheromatous disease.

Main Methods:

  • Review of existing literature on CCB mechanisms and effects in animal models.
  • Analysis of results from clinical trials such as INTACT, Montreal Nicardipine Trial, and MIDAS.

Main Results:

  • CCBs demonstrated beneficial effects in animal models of atherogenesis.

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  • Clinical trials suggest a demonstrable anti-atherosclerotic action in patients, though the extent is not fully established.

    • Conclusions:

    • Emerging evidence supports an anti-atherosclerotic role for CCBs in humans.
    • Further investigation is required to fully establish the clinical importance of CCBs in managing atherosclerosis.