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Related Experiment Videos

Amlodipine and vascular hypertrophy

O Stepien1, L Iouzalen, T Herembert

  • 1Laboratory of Pharmacology, Université René Descartes and CNRS URA 1482, Faculté de Médecine Necker, Paris, France.

International Journal of Cardiology
|March 6, 1998
PubMed
Summary
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Amlodipine inhibits vascular smooth muscle cell growth and proliferation, particularly in response to basic fibroblast growth factor. This drug

Area of Science:

  • Cardiovascular Pharmacology
  • Cell Biology

Background:

  • Vascular hypertrophy in atherosclerosis and hypertension involves increased vascular smooth muscle cell (VSMC) growth.
  • Spontaneously hypertensive rats (SHR) exhibit exaggerated VSMC growth compared to normotensive controls.
  • In vitro VSMC models are crucial for studying drug mechanisms like amlodipine's effects.

Purpose of the Study:

  • To investigate how amlodipine affects VSMC growth and proliferation.
  • To determine the specific mechanisms and cell cycle phase targeted by amlodipine.
  • To assess amlodipine's impact on VSMC response to basic fibroblast growth factor (bFGF).

Main Methods:

  • VSMCs were isolated from SHR and Wistar Kyoto (WKY) rats.
  • Cell proliferation was assessed by DNA synthesis and cell counting.

Related Experiment Videos

  • Amlodipine's effects were studied at different concentrations and addition times, including cell cycle analysis.

    • Main Results:

    • Amlodipine inhibited VSMC growth and bFGF-induced DNA synthesis in a concentration-dependent manner.
    • The drug exerts its inhibitory effect early in the G1 phase of the cell cycle.
    • Amlodipine showed similar efficacy in inhibiting both SHR- and WKY-derived VSMCs.

    Conclusions:

    • Amlodipine's modulation of VSMC growth and proliferation may contribute to reducing vascular hypertrophy in SHR.
    • These findings support amlodipine's potential antihypertensive and antiatherogenic properties.
    • Amlodipine's inhibition of VSMC migration further supports its antiatherogenic role.