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Effect of aging on foveolar choroidal circulation
J E Grunwald1, S M Hariprasad, J DuPont
1Department of Ophthalmology, School of Medicine, University of Pennsylvania, Philadelphia, USA.
Archives of Ophthalmology (Chicago, Ill. : 1960)
|March 6, 1998
Summary
Foveolar choroidal blood flow (ChBFlow) significantly decreases with age in normal eyes. This age-related decline in ChBFlow is linked to changes in the choriocapillaries.
Area of Science:
- Ophthalmology
- Physiology
- Medical Imaging
Background:
- Choroidal blood flow (ChBFlow) is crucial for maintaining the health of the retina.
- Understanding age-related changes in ChBFlow is important for diagnosing and managing ocular diseases.
Purpose of the Study:
- To investigate the impact of aging on foveolar choroidal blood flow (ChBFlow) in healthy individuals.
- To correlate ChBFlow parameters with subject age.
Main Methods:
- Choroidal blood flow (ChBFlow) was measured using laser Doppler flowmetry in 29 healthy subjects (ages 15-76).
- Relative choroidal blood velocity (ChBVel), choroidal blood volume (ChBVol), and ChBFlow were assessed in the foveolar region.
- Subjects fixated on a laser beam during measurements.
Main Results:
- A significant negative correlation was found between ChBVol and age (R=-0.52, P=.004).
- Choroidal blood flow (ChBFlow) also showed a significant negative correlation with age (R=-0.54, P=.003).
- No significant correlation was observed between ChBVel and age (R=0.07, P=.70).
Conclusions:
- Foveolar choroidal blood flow (ChBFlow) diminishes with increasing age in normal subjects.
- This age-related decrease in ChBFlow may be attributed to reduced density and diameter of choriocapillaries.
- Choroidal blood volume (ChBVol) also decreases with age.