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Specific antibody to Cryptococcus neoformans alters human leukocyte cytokine synthesis and promotes T-cell
A Vecchiarelli1, C Retini, C Monari
1Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy. vecchiar@unipg.it
Infection and Immunity
|March 6, 1998
Abstract:
Addition of a monoclonal antibody which binds the Cryptococcus neoformans capsule to suspensions of human monocytes, T lymphocytes, and cryptococcal cells (i) enhances interleukin-1beta (IL-1beta), tumor necrosis factor alpha, and IL-2 production; (ii) reduces IL-10 secretion; and (iii) promotes T-cell proliferation. The ability of specific antibody to influence cytokine production and lymphoproliferation suggests a mechanism by which humoral immunity can influence cell-mediated immunity.