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Serum complement sensitivity as a key factor in Lyme disease ecology

K Kurtenbach1, H S Sewell, N H Ogden

  • 1Department of Zoology, University of Oxford, United Kingdom. kku@mail.nerc-oxford.ac.uk

Infection and Immunity
|March 6, 1998
PubMed
Summary

Animal sera show varying effects on Borrelia burgdorferi sensu lato, impacting bacterial survival. Complement-mediated effects in host serum are crucial for Lyme borreliosis ecology.

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Area of Science:

  • Microbiology
  • Immunology
  • Ecology

Background:

  • Lyme borreliosis is a tick-borne disease caused by Borrelia burgdorferi sensu lato.
  • Understanding the factors influencing Borrelia survival in different hosts is critical for disease ecology.

Purpose of the Study:

  • To investigate the sensitivity of Borrelia burgdorferi sensu lato to various animal sera.
  • To determine the role of complement in the interaction between Borrelia and host sera.

Main Methods:

  • Analysis of Borrelia burgdorferi sensu lato sensitivity to different animal sera.
  • Observation of complement-mediated borreliacidal effects.

Main Results:

  • Complement-mediated borreliacidal effects were observed with specific host serum and Borrelia genospecies combinations.

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  • The observed species-specific patterns of bacterial viability and lysis correlate with known host reservoir competence for Borrelia burgdorferi sensu lato.

    • Conclusions:

    • Complement plays a significant role in the differential susceptibility of Borrelia burgdorferi sensu lato to animal sera.
    • Complement-mediated interactions are key determinants in the global ecology and transmission dynamics of Lyme borreliosis.