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[Rheologic changes with streptokinase--experimental studies]

K Sedlarik, H P Klöcking

    Folia Haematologica (Leipzig, Germany : 1928)
    |January 1, 1979
    PubMed
    Summary

    Awelysin treatment improved blood flow in dogs with femoral artery stenosis. This was due to reduced fibrinogen levels and increased fibrinogen degradation products, aiding circulation below the blockage.

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    Area of Science:

    • Cardiovascular physiology
    • Pharmacology
    • Veterinary medicine

    Context:

    • Artificial stenosis of the femoral artery in canine models provides a platform to study circulatory impairments.
    • Fibrinogen plays a crucial role in blood coagulation and can contribute to vascular obstruction.

    Purpose:

    • To investigate the effect of Awelysin on blood flow in a canine model of femoral artery stenosis.
    • To determine the underlying mechanisms responsible for any observed changes in blood flow.

    Summary:

    • Administration of Awelysin (96,000 IU/kg initial dose, followed by 1200 IU/kg/min infusion) increased blood flow distal to an artificially induced femoral artery stenosis in dogs.
    • This therapeutic effect correlated with a reduction in plasma fibrinogen levels and a concurrent rise in fibrinogen degradation products.

    Impact:

    • Demonstrates the potential of Awelysin as a therapeutic agent for improving circulation in conditions involving arterial stenosis and coagulation.
    • Highlights the role of fibrinogen modulation in restoring blood flow in vascular obstructions.

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