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Related Experiment Videos

Ovarian function after bone marrow transplantation during childhood

E Thibaud1, K Rodriguez-Macias, C Trivin

  • 1Pediatric Endocrinology Unit, Université Paris V and Hopital Necker-Enfants Malades, France.

Bone Marrow Transplantation
|March 7, 1998
PubMed
Summary

Childhood conditioning for bone marrow transplantation (BMT) frequently causes ovarian failure, impacting puberty and estrogen secretion. Early intervention with substitutive treatment may be needed for growth and sexual development.

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Area of Science:

  • Pediatric Oncology
  • Reproductive Endocrinology
  • Hematology

Background:

  • Bone marrow transplantation (BMT) conditioning protocols can lead to ovarian failure in young girls.
  • Assessing the long-term impact of BMT conditioning on ovarian function is crucial for pediatric patients.

Purpose of the Study:

  • To evaluate ovarian function and pubertal development in girls undergoing BMT conditioning.
  • To determine the relationship between conditioning regimens and the incidence of ovarian failure.

Main Methods:

  • Prospective monitoring of 31 girls undergoing BMT, divided into groups based on conditioning (chemotherapy alone or with varying irradiation doses).
  • Assessment of breast development, menstrual history, and basal plasma gonadotropin levels (follicle-stimulating hormone and luteinizing hormone).

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Main Results:

  • Complete ovarian failure occurred in 23 out of 31 girls by age 16.3 years.
  • Chemotherapy plus irradiation significantly increased the risk of ovarian failure compared to chemotherapy alone.
  • Elevated follicle-stimulating hormone and luteinizing hormone levels indicated impaired ovarian function.

Conclusions:

  • Childhood BMT conditioning frequently results in impaired estrogen secretion and ovarian failure.
  • Substitutive hormonal therapy may be necessary to support pubertal progression and sexual development in survivors.