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Late onset Epstein-Barr virus-associated lymphoproliferative disease after allogeneic bone marrow transplant

S H Abhyankar1, K Y Chiang, J P McGuirk

  • 1Department of Medicine, University of South Carolina and Richland Memorial Hospital, Columbia 29203, USA.

Bone Marrow Transplantation
|March 7, 1998
PubMed

We report a patient who developed breast masses 17 months after a T cell-depleted partially mismatched related donor (PMRD) bone marrow transplant (BMT) for chronic myeloid leukemia. The patient had severe chronic graft-versus-host disease (GVHD) and the masses were due to Epstein-Barr virus (EBV) lymphoproliferative disease (LPD). The patient expired from fungal pneumonia after chemotherapy for the EBV-LPD.

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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