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In vivo mapping of nucleosomes using psoralen-DNA crosslinking and primer extension
1Institut fur Zellbiologie, ETH-Hönggerberg, CH-8093 Zurich, Switzerland.
Nucleic Acids Research
|April 29, 1998
Abstract:
By the use of psoralen crosslinking and primer extension, a method was developed which allows the analysis of chromatin structure in vivo. Using a yeast minichromosome, >9 nucleosomes were mapped with a resolution of at least +/-30 bp.