Related Experiment Videos
Pancreatic enhancement and pulse sequence analysis using low-dose mangafodipir trisodium
W W Mayo-Smith1, W Schima, S Saini
1Department of Radiology, Massachusetts General Hospital, Boston, MA, USA.
AJR. American Journal of Roentgenology
|March 10, 1998
Summary
Low-dose mangafodipir trisodium (5 mumol/kg) significantly enhances pancreatic tissue visualization across three T1-weighted MRI sequences. The fat-suppressed spin-echo sequence demonstrated the best signal and contrast for pancreatic imaging.
Area of Science:
- Radiology
- Medical Imaging
- Gastroenterology
Background:
- Pancreatic MRI requires effective contrast agents for optimal visualization.
- Mangafodipir trisodium is a potential MRI contrast agent for abdominal imaging.
Purpose of the Study:
- To evaluate pancreatic enhancement using low-dose mangafodipir trisodium (5 mumol/kg).
- To compare the efficacy of three different T1-weighted pulse sequences for pancreatic imaging with this agent.
Main Methods:
- Fifteen patients underwent MRI with T1-weighted gradient-recalled echo, spin-echo, and fat-suppressed spin-echo sequences.
- Imaging was performed before and after a 5 mumol/kg dose of mangafodipir trisodium.
- Signal-to-noise (SNR) and contrast-to-noise (CNR) ratios were calculated for pancreatic tissue.
Main Results:
- Mangafodipir trisodium significantly increased pancreatic SNR across all tested T1-weighted sequences (p < .001).
- Fat-suppressed and gradient-recalled echo sequences yielded the highest SNRs.
- CNR between normal pancreas and tumors improved (p < .05), with the fat-suppressed sequence showing the best results.
Conclusions:
- Low-dose mangafodipir trisodium (5 mumol/kg) provides marked pancreatic enhancement.
- The enhanced T1-weighted spin-echo fat-suppressed sequence is superior for achieving high SNR and CNR in pancreatic MRI.