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Related Experiment Videos

Systemic sclerosis: using high-resolution CT to detect lung disease in children

J M Seely1, L T Jones, C Wallace

  • 1Department of Radiology, British Columbia's Children's Hospital, Vancouver, Canada.

AJR. American Journal of Roentgenology
|March 10, 1998
PubMed
Summary

High-resolution CT (HRCT) reveals significant interstitial lung disease in children with systemic sclerosis, with 91% showing abnormalities. Pulmonary disease is common, even with normal chest X-rays.

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Area of Science:

  • Pediatric Rheumatology
  • Pulmonology
  • Radiology

Background:

  • Systemic sclerosis in children can affect multiple organs, including the lungs.
  • Interstitial lung disease (ILD) is a serious complication, but its prevalence and severity in pediatric systemic sclerosis are not well-defined.

Purpose of the Study:

  • To determine the prevalence and severity of interstitial lung disease (ILD) in children with systemic sclerosis using high-resolution computed tomography (HRCT).

Main Methods:

  • Eleven children (mean age 11 years) with systemic sclerosis underwent HRCT, chest radiography, and pulmonary function testing.
  • HRCT scans were evaluated for ground-glass attenuation, honeycombing, and other abnormalities, with profusion scores calculated.
  • Follow-up HRCT was performed on eight patients to assess disease progression.

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Main Results:

  • HRCT identified ILD in 91% of patients, significantly more than chest radiography (20%).
  • Common HRCT findings included ground-glass attenuation (73%), subpleural micronodules (64%), and linear opacities (55%).
  • Pulmonary function tests were abnormal in 70% of patients with HRCT-confirmed lung disease, correlating with ground-glass attenuation severity.

Conclusions:

  • HRCT is a sensitive tool for detecting significant pulmonary disease in children with systemic sclerosis.
  • Pulmonary involvement should be suspected in pediatric systemic sclerosis patients, regardless of chest radiograph findings.
  • Early detection and monitoring of ILD are crucial in managing pediatric systemic sclerosis.