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Herniated cervical intervertebral discs: histological and immunohistochemical characteristics
H Baba1, Y Maezawa, N Furusawa
1Department of Orthopaedic Surgery, Fukui Medical School, Japan.
European Journal of Histochemistry : EJH
|January 1, 1997
Summary
Histological analysis of herniated cervical discs reveals significant tissue reactions. These changes, including new blood vessel formation and immune cell presence, correlate with herniation extent and location.
Area of Science:
- Spinal Surgery
- Orthopedics
- Pathology
Background:
- Cervical disc herniation is a common condition.
- Understanding the biological processes involved is crucial for treatment.
Purpose of the Study:
- To investigate the histological and immunohistochemical changes in and around herniated cervical intervertebral discs.
- To correlate these changes with the extent and location of herniated disc material.
Main Methods:
- Harvesting of 28 herniated cervical discs en bloc during surgery.
- Histological examination of discs and surrounding tissues.
- Immunohistochemical analysis using antibodies for von Willebrand factor, matrix metalloproteinase-3, CD68, and interleukin-1 beta.
Main Results:
- Degeneration of the cartilaginous endplate and torn annulus fibrosus were observed.
- Neovascularization was detected in 25% of uncontained and 38% of contained hernias.
- Cells positive for matrix metalloproteinase-3, CD68, and interleukin-1 beta were identified within the herniated discs.
Conclusions:
- The histological and immunohistochemical reactions in cervical disc herniation are significant.
- The degree of these tissue reactions correlates with the extent and location of the herniated disc material.