Related Experiment Videos
Anthelmintic induced congenital malformations in sheep embryos using netobimin
M Navarro1, C Cristofol, A Carretero
1Department of Anatomy and Embryology, Veterinary Faculty, Autonomous University of Barcelona, Bellaterra, Spain.
The Veterinary Record
|March 10, 1998
Summary
Netobimin, a benzimidazole drug, caused congenital malformations and abortions in 60% of lambs when given to ewes during pregnancy. Skeletal, renal, and novel vascular abnormalities were observed, highlighting teratogenic risks.
Area of Science:
- Veterinary medicine
- Toxicology
- Developmental biology
Background:
- Benzimidazole compounds are known teratogens in animals.
- Netobimin is a prodrug of a benzimidazole compound.
Purpose of the Study:
- To investigate the teratogenic effects of netobimin in Manchega ewes.
- To document the types and prevalence of congenital malformations induced by netobimin.
Main Methods:
- 14 pregnant Manchega ewes were orally administered 20 mg/kg netobimin on day 17 of gestation.
- Lambs were examined for congenital malformations using radiological, dissection, and vascular injection techniques.
Main Results:
- 60% of lambs exhibited congenital malformations or abortions.
- Primary malformations included skeletal and renal defects.
- Vascular malformations were observed for the first time in association with netobimin exposure.
Conclusions:
- Netobimin exhibits significant teratogenic potential in sheep.
- The study identified novel vascular abnormalities alongside known skeletal and renal defects.
- Findings underscore the importance of embryological considerations for drug safety in pregnant animals.