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Updated: Aug 19, 2026

A Murine Model of Cervical Spinal Cord Injury to Study Post-lesional Respiratory Neuroplasticity
Published on: May 28, 2014
[Respiration mechanics in tetraplegia]
1Service de Pneumologie, Hôpital universitaire Erasme, et laboratoire de Physiologie cardio-respiratoire, Université libre de Bruxelles.
Abstract:
Patients with quadriplegia due to transection of the lower cervical cord show, on spirographic examination, a marked decrease in vital capacity and its two components, i.e. inspiratory capacity (i.c.) and expiratory reserve volume (ERV). The loss of IC results partly from the decreased inspiratory muscle strength consecutive to the intercostal muscle paralysis but mostly from a reduction in the distensibility of the lungs and the rib cage. The reduction in ERV is related to the paralysis of all the well-recognized muscles of expiration (abdominals, interosseous internal intercostals); however, the clavicular portion of the pectoralis major allows these patients to maintain a small ERV.
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