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[The optimization of the hemodynamic characteristics in patients with ischemic heart disease and circulatory failure
Insights
Combined therapy including glucose-insulin-potassium and glutaminic acid significantly improves cardiovascular function in patients with ischemic heart disease compared to basic therapy alone.
Area of Science:
- Cardiology
- Internal Medicine
Background:
- Ischemic heart disease (IHD) presents challenges in managing effort angina and circulatory insufficiency.
- Functional Class II-III (NYHA) indicates moderate to severe limitations in daily activities due to IHD.
Purpose of the Study:
- To compare the efficacy of combined therapy versus basic therapy in patients with IHD.
- To evaluate the impact of glucose-insulin-potassium mixture plus glutaminic acid on cardiohemodynamic interrelations.
Main Methods:
- Evaluation of 65 patients with ischemic heart disease.
- Comparative assessment of combined therapy (basic antianginal agents + glucose-insulin-potassium + glutaminic acid) versus basic therapy alone.
- Assessment of postexercise levels, arterial system coordination, and left ventricular inotropic function.
Main Results:
- Combined therapy demonstrated superior restoration of cardiohemodynamic interrelations.
- Significant reduction in postexercise levels was observed with combined therapy.
- Improved coordination of arterial system function and augmented left ventricular inotropic function were noted.
Conclusions:
- Combined therapy is more effective than basic therapy for improving cardiovascular function in IHD patients.
- The addition of glucose-insulin-potassium and glutaminic acid enhances the benefits of standard antianginal treatments.
- This combined approach offers a promising strategy for managing effort angina and circulatory insufficiency in IHD.
Abstract:
On the basis of findings from evaluation of 65 patients with ischemic heart disease presenting with functional class II-III effort angina and FC II-III circulatory insufficiency (NYHA) a comparative assessment was carried out of efficacy of combined therapy involving basic antianginal agents and glucose-insulin-potassium mixture plus glutaminic acid versus solitary basic therapy. It has been shown that combined versus basic therapy is much more capable of restoring cardiohemodynamic interrelations. This was evidenced by a significant reduction of the postexercise level, improvement in the coordination of work of the arterial system, and augmentation of the left ventricular inotropic function.