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[Immune system function in patients with acute pyelonephritis]
As many as 296 patients with acute pyelonephritis were evaluated for parameters characterizing their immunological status. The results were as follows: decreased levels of T-lymphocytes, T-helpers, and immunoregulatory index in 42%, 87% and 72% respectively. In normal indices of spontaneous test with nitroblue tetrazolium stimulated below the norm was in 71% of cases. A study involving the use of monoclonal antibodies revealed no changes in the EK-cells counts, while their functional activity was decreased in 52% of patients. The functional activity of lymphocytes in the reaction of blast transformation in response to phytohemagglutinin and PWM was running down in 83% and 75% of cases respectively. With high levels of blood serum IgA and IgM the number of the immune complexes was noted to be on the increases in 68% of patients. The level of spontaneous productions of IL-1 was normal whereas that of IL-2 elevated, with the stimulated production of there mediators in AP patients being significantly below the norm.
As many as 296 patients with acute pyelonephritis were evaluated for parameters characterizing their immunological status. The results were as follows: decreased levels of T-lymphocytes, T-helpers, and immunoregulatory index in 42%, 87% and 72% respectively. In normal indices of spontaneous test with nitroblue tetrazolium stimulated below the norm was in 71% of cases. A study involving the use of monoclonal antibodies revealed no changes in the EK-cells counts, while their functional activity was decreased in 52% of patients. The functional activity of lymphocytes in the reaction of blast transformation in response to phytohemagglutinin and PWM was running down in 83% and 75% of cases respectively. With high levels of blood serum IgA and IgM the number of the immune complexes was noted to be on the increases in 68% of patients. The level of spontaneous productions of IL-1 was normal whereas that of IL-2 elevated, with the stimulated production of there mediators in AP patients being significantly below the norm.