Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Active immobilized antibiotics based on metal hydroxides

J F Kennedy, J D Humphreys

    Antimicrobial Agents and Chemotherapy
    |May 1, 1976
    PubMed
    Summary

    Researchers created insoluble antibiotic derivatives using metal hydroxides, maintaining antibacterial activity. This offers a simple, cost-effective method for slow-release antibiotic products.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Falcipain-2: A review on structurally diverse non-peptide inhibitors.

    International journal of biological macromolecules·2025
    Same author

    Delineating the inherent functional descriptors and biofunctionalities of pectic polysaccharides.

    Carbohydrate polymers·2021
    Same author

    Cr(VI) adsorption on the blends of Henna with chitosan microparticles: Experimental and statistical analysis.

    International journal of biological macromolecules·2018
    Same author

    Immobilization of yeast inulinase on chitosan beads for the hydrolysis of inulin in a batch system.

    International journal of biological macromolecules·2016
    Same author

    Welan gum: microbial production, characterization, and applications.

    International journal of biological macromolecules·2014
    Same author

    Immobilization of β-d-galactosidase from Kluyveromyces lactis on functionalized silicon dioxide nanoparticles: characterization and lactose hydrolysis.

    International journal of biological macromolecules·2012

    Area of Science:

    • Medicinal Chemistry
    • Materials Science
    • Microbiology

    Background:

    • Antibiotic resistance necessitates novel drug delivery systems.
    • Immobilization of antibiotics can improve stability and control release.
    • Metal hydroxides offer potential matrices for drug delivery applications.

    Purpose of the Study:

    • To synthesize insoluble antibiotic derivatives using water-insoluble metal hydroxides.
    • To evaluate the antibacterial activity of these novel derivatives.
    • To explore the potential of metal hydroxides as matrices for antibiotic immobilization.

    Main Methods:

    • Chelation process using water-insoluble hydroxides of zirconium (IV), titanium (IV), iron (II), vanadium (III), and tin (II).
    • Preparation of insoluble derivatives of cyclic peptide antibiotics (neomycin, polymyxin B, streptomycin, ampicillin, penicillin G, chloramphenicol).
    • Antibacterial activity testing against gram-positive and gram-negative bacteria, utilizing colored organisms for enhanced assay sensitivity.

    Main Results:

    • Insoluble antibiotic derivatives retained significant antibacterial activity against susceptible bacteria.
    • Chelation with zirconium hydroxide yielded derivatives of various antibiotics that mirrored parent compound activity.
    • Some metal hydroxides exhibited inherent antibacterial properties via complex formation with bacteria.

    Conclusions:

    • Metal hydroxides serve as effective, simple, and inexpensive matrices for antibiotic immobilization.
    • The resulting insoluble antibiotic derivatives demonstrate potential for slow-release properties.
    • This approach offers a viable strategy for developing new antibacterial products with enhanced characteristics.

    Related Experiment Videos