Related Experiment Video
Updated: Aug 9, 2026

In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes
Published on: August 17, 2022
Cytotoxic and antimalarial alkaloids from Brunsvigia littoralis
Abstract:
Four known alkaloids, lycorine (1), 1,2-di-O-acetyllycorine (2), ambelline (3), and crinine (4) were isolated from the bulbs of Brunsvigia littoralis (Amaryllidaceae). 1H- and 13C-NMR spectra of 2 were completely assigned by means of 1D- and 2D-NMR techniques. The alkaloids (1-4) together with the synthesised 11-O-acetylambelline (3a) and 3-O-acetylcrinine (4a) were tested for antimalarial activity with two strains of cultured Plasmodium falciparum and for cytotoxicity with BL6 mouse melanoma cells. Structures 1 and 2 exhibited both antimalarial and cytotoxic activity.
Related Concept Videos
Drugs that Stabilize Microtubules
Physical Properties of Amines
Drugs that Destabilize Microtubules
Antifungal Agents
Anthelminthic Agents
Antiprotozoal Agents

