Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Cisplatin-induced non-convulsive encephalopathy

O Lyass¹, A Lossos, A Hubert

¹Department of Oncology, Hadassah University Hospital and Hebrew University-Hadassah Medical School, Jerusalem, Israel.

Anti-Cancer Drugs

|March 10, 1998

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Unleashing the power of anti-HER2 therapies in metastatic colorectal cancer: paving the way for a brighter future.

ESMO gastrointestinal oncology·2026

Same author

Treatments and clinical outcomes in stage II colon cancer patients with 12-gene Oncotype DX Colon Recurrence Score® assay-guided therapy: real-world data.

ESMO open·2024

Same author

Common founder BRCA2 pathogenic variants and breast cancer characteristics in Ethiopian Jews.

Breast cancer research and treatment·2022

Same author

A new electron diffraction approach for structure refinement applied to Ca<sub>3</sub>Mn<sub>2</sub>O<sub>7</sub>.

Acta crystallographica. Section A, Foundations and advances·2021

Same author

A novel founder MSH2 deletion in Ethiopian Jews is mainly associated with early-onset colorectal cancer.

Familial cancer·2021

Same author

Prognostic utility of the assessment of diastolic function in patients undergoing cardiac resynchronization therapy.

International journal of cardiology·2021

Cisplatin chemotherapy can cause rare, reversible non-convulsive encephalopathy. This case suggests neurotoxicity may stem from regional endovascular injury, not direct brain damage.

Area of Science:

Neuroscience
Oncology
Pharmacology

Background:

Cisplatin is a cornerstone chemotherapy for ovarian cancer.
Neurotoxicity is a known adverse effect of cisplatin.
The pathogenesis of cisplatin-induced encephalopathy remains unclear.

Observation:

An 84-year-old woman with ovarian adenocarcinoma experienced two episodes of reversible non-convulsive encephalopathy.
Symptoms included acute confusional state, homonymous hemianopia, and hemihypesthesia.
Neurological events occurred 7-10 days post-cisplatin chemotherapy.

Findings:

Brain MRI revealed pre-existing cerebral microvascular changes.
EEG showed periodic lateralized epileptiform discharges and background slowing.

Related Experiment Videos

The temporal association confirmed cisplatin as the likely causative agent.

Implications:

This case expands the known spectrum of cisplatin neurotoxicity.
The presentation suggests posterior reversible encephalopathy syndrome (PRES)-like features.
Findings support a hypothesis of cisplatin-induced regional endovascular injury as the primary mechanism.