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Related Experiment Videos

Synchronization of pacemaker cell firing by weak ELF fields: simulation by a circuit model

L J Bruner1, J R Harvey

  • 1Department of Physics, University of California, Riverside 92521, USA.

Bioelectromagnetics
|March 10, 1998
PubMed
Summary

Extremely low frequency (ELF) electric fields can synchronize neural firing patterns. Even with added noise, subharmonic locking occurs at specific frequencies, demonstrating a novel neural entrainment mechanism.

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Area of Science:

  • Neuroscience
  • Computational Biology
  • Biophysics

Background:

  • Neural entrainment to external stimuli is a known phenomenon.
  • Extremely low frequency (ELF) electric fields can synchronize neural firing.
  • Direct neural excitation requires high current densities, but entrainment of pacemaker cells requires less.

Purpose of the Study:

  • To model neural spike generation and investigate entrainment by ELF currents.
  • To characterize the stimulus-response relationship under varying current conditions.
  • To determine the current densities required for subharmonic locking.

Main Methods:

  • Developed a neural spike generator circuit model.
  • Simulated repetitive action potential generation in a patch of excitable membrane.

Related Experiment Videos

  • Applied direct current (DC) and alternating current (AC) with superimposed noise.

    • Main Results:

    • DC current variations produced a smooth stimulus-response characteristic.
    • Superposed AC current caused subharmonic locking at 30, 20, 15 Hz and higher.
    • Subharmonic locking persisted at 30, 20, 15 Hz even with superimposed noise.
    • Observed subharmonic locking at root mean square AC current densities of approximately 10(-5) A-m(-2).

    Conclusions:

    • Neural spike generators exhibit subharmonic locking to ELF currents.
    • This locking phenomenon is robust and observable even in the presence of physiological noise.
    • The model provides insights into neural entrainment mechanisms at low current densities.