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Long-term outcome among patients with juvenile rheumatoid arthritis
1Division of Rheumatology, Department of Pediatrics, Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA. Sprahal@aol.com
Insights
Juvenile rheumatoid arthritis (JRA) is a chronic inflammatory disease impacting joints and extra-articular tissues. This review examines JRA
Area of Science:
- Rheumatology
- Pediatric Medicine
- Immunology
Background:
- Juvenile rheumatoid arthritis (JRA) is a chronic inflammatory condition affecting joints and other tissues.
- Understanding the long-term outcomes of JRA is crucial for patient management.
Purpose of the Study:
- To review various studies addressing the long-term outcomes of JRA.
- To provide a comprehensive overview of disease outcome, mortality, iridocyclitis, and stature in JRA patients.
- To describe assessment tools and the role of laboratory and radiological evaluations in predicting JRA outcomes.
Main Methods:
- Literature review of studies on JRA long-term outcomes.
- Analysis of functional, educational, and employment status in JRA patients.
- Description of outcome assessment instruments and predictive value of lab/radiological data.
Main Results:
- The review synthesizes findings on disease progression, survival rates, eye inflammation (iridocyclitis), and growth disturbances (stature).
- It evaluates the impact of JRA on patients' functional capabilities, education, and employment.
- The utility of various assessment tools and predictive markers is discussed.
Conclusions:
- Long-term outcomes of JRA encompass disease course, mortality, ocular and physical development.
- Comprehensive assessment requires evaluating functional, educational, and employment status alongside clinical parameters.
- Laboratory and radiological findings play a role in predicting prognosis.
Abstract:
Juvenile rheumatoid arthritis (JRA) is a chronic inflammatory disease primarily affecting the joints but also extra articular tissue. The long-term outcome of JRA has different aspects, which include disease outcome, mortality, iridocyclitis and stature. Several studies, which have addressed these issues, are reviewed in this article. In addition, functional, educational and employment status of patients with JRA are also reviewed. To facilitate better understanding of these various studies, a description of the terminology used in defining disease is provided. Several of the instruments that are available for assessing outcome among patients are described. The role of laboratory and radiological evaluation in predicting outcome is also addressed.