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Related Experiment Videos

[Pathophysiological background of transient hyperphosphatasemia]

M Suzuki1, T Okazaki, M Asahara

  • 1Testing Department A, Mitsubishi Kagaku Bio-Clinical Laboratories, Inc., Tokyo.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|March 11, 1998
PubMed
Summary

Transient hyperphosphatasemia (TH) in 23 cases was studied for its link to viral infections. Results indicate a potential association, with specific viral antibodies detected in a notable percentage of patients.

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Area of Science:

  • Pediatrics
  • Virology
  • Biochemistry

Context:

  • Transient hyperphosphatasemia (TH) is a rare condition characterized by elevated serum alkaline phosphatase levels.
  • The etiology of TH remains largely unknown, with various factors proposed.
  • Viral infections are increasingly recognized as potential triggers for various pediatric conditions.

Purpose:

  • To investigate the potential association between viral infections and the occurrence of transient hyperphosphatasemia (TH) in pediatric cases.
  • To identify specific viral agents that may be linked to TH.
  • To contribute to understanding the pathophysiology of TH.

Summary:

  • A study examined 23 pediatric cases diagnosed with transient hyperphosphatasemia (TH).
  • Clinical observations suggested a concurrent viral infection in a significant proportion of these patients.

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  • Antibody titer measurements revealed elevated levels against Echo 22, Enterovirus 71, and Coxsackie B5 in 20.0%, 11.1%, and 11.1% of the cases, respectively.

    • Impact:

    • This research suggests a potential etiological link between specific enteroviruses and transient hyperphosphatasemia in children.
    • Findings may guide future diagnostic approaches for TH, considering viral screening.
    • Further research can elucidate the precise mechanisms by which viral infections trigger TH.