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Published on: May 29, 2020
Autoimmune ovarian disease: mechanism of disease induction and prevention
1Department of Pathology, University of Virginia, Charlottesville 22908, USA. kst7k@Virginia.edu
Abstract:
Investigation of the versatile models for autoimmunity of the ovary and other selected organs has contributed to our understanding of the following aspects of autoimmunity: the mechanism of T cell molecular mimicry; T-->B epitope spreading, as a basis for autoantibody diversification, and as a link between organ-specific and systemic autoimmunity; the localization of genetic loci potentially influencing multiple autoimmune diseases; and the elucidation of regulatory T cells as a component of physiological self tolerance.
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