Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mediators of inflammation

R Sacca1, C A Cuff, N H Ruddle

  • 1Department of Epidemiology, Yale University School of Medicine, New Haven, CT 06520-8034, USA.

Current Opinion in Immunology
|March 11, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Potential predictive biomarkers of adalimumab response in patients with hidradenitis suppurativa.

The British journal of dermatology·2021
Same author

Lymphotoxin redux.

Immunology today·2014
Same author

Lymphotoxin production in AIDS.

Immunology today·2014
Same author

In vitro and in vivo characterization of A-940894: a potent histamine H4 receptor antagonist with anti-inflammatory properties.

British journal of pharmacology·2009
Same author

Murine neurofibroma reversion by antisense RNA for HTLV-I tax.

Science in China. Series C, Life sciences·2008
Same author

Tertiary lymphoid tissues generate effector and memory T cells that lead to allograft rejection.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2007

Inflammatory mediators like cytokines and chemokines are key in autoimmune disease and surprisingly also in lymphoid organ development. This suggests shared mechanisms between immunity and organ formation, impacting disease progression.

Area of Science:

  • Immunology
  • Developmental Biology
  • Autoimmune Diseases

Background:

  • Cytokines and chemokines are known inflammatory mediators.
  • Their roles in autoimmune diseases have been extensively studied.
  • Recent evidence suggests novel functions beyond inflammation.

Purpose of the Study:

  • To explore the unexpected roles of inflammatory mediators in lymphoid organ development.
  • To connect inflammatory processes with lymphoid organogenesis.
  • To investigate implications for autoimmune disease mechanisms, including determinant spreading.

Main Methods:

  • Review of therapeutic studies.
  • Analysis of data from genetically engineered animal models.
  • Synthesis of recent evidence on inflammatory mediators.

Related Experiment Videos

Main Results:

  • Inflammatory mediators play crucial roles in lymphoid organ development.
  • Inflammation and lymphoid organogenesis share common underlying elements.
  • These shared elements have implications for determinant spreading in autoimmune diseases.

Conclusions:

  • Inflammatory mediators are integral to both immune responses and lymphoid organ development.
  • The dual role of these mediators suggests a fundamental link between immunity and organogenesis.
  • Understanding this link is critical for advancing autoimmune disease research and therapeutic strategies.