Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gamma delta cells regulate autoimmunity

A Hayday1, L Geng

  • 1Dept of Molecular, Cell and Developmental Biology, Yale University, New Haven, CT 06511, USA. adrian.hayday@yale.edu

Current Opinion in Immunology
|March 11, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Impact of hemodynamic pattern of non-culprit vessel stenosis on the long-term prognosis in patients with acute ST-segment elevation myocardial infarction].

Zhonghua xin xue guan bing za zhi·2025
Same author

[Beneficial effects of extravascular lung water index-guided volum management in patients with cardiogenic shock].

Zhonghua xin xue guan bing za zhi·2024
Same author

Evidence of the outcome and safety of upper pole vs. other pole access single puncture PCNL for kidney stones: which is better?

European review for medical and pharmacological sciences·2023
Same author

[Fibroblasts overpressing WNT2b cause impairment of intestinal mucosal barrier].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University·2023
Same author

[The value of a nomogram based on clinical data and contrast enhanced CT radiomics in the preoperative prediction of Epstein-Barr virus-associated gastric carcinoma].

Zhonghua yi xue za zhi·2022
Same author

Response to "caution regarding interpretations of intrauterine γδ T cells in protection against experimental vaginal candidiasis".

Mucosal immunology·2021
Same journal

A blind spot of human T cell immunology: epitope specificity in secondary lymphoid organs.

Current opinion in immunology·2026
Same journal

Germinal center responses at barrier organ sites.

Current opinion in immunology·2026
Same journal

Ocular sarcoidosis: from clinical signs to targeted interventions.

Current opinion in immunology·2026
Same journal

On or within: spatial determinants of antigen handling in the nasal turbinates.

Current opinion in immunology·2026
Same journal

Decoding the complexity of intestinal immunity with spatial transcriptomics.

Current opinion in immunology·2026
Same journal

Reconsidering the immunological aspects of solid-phase assays for antiphospholipid antibodies detection.

Current opinion in immunology·2026
See all related articles

Gamma delta cells are key players in autoimmune diseases. These immune cells, unlike others, show significant roles in tissue damage and disease progression in vivo.

Area of Science:

  • Immunology
  • Autoimmune Diseases

Background:

  • Gamma delta cells are implicated in autoimmune disease pathogenesis.
  • Their expansion in germ-free mice suggests autoantigen recognition.
  • Gamma delta-cell-deficient mice lack severe foreign antigen response defects.

Purpose of the Study:

  • To investigate the role of gamma delta cells in autoimmune disease.
  • To explore the contribution of gamma delta cells as unidentified players in disease models.

Main Methods:

  • Analysis of gamma delta cell behavior in germ-free and deficient mouse models.
  • Evaluation of immune responses to foreign antigens.
  • Assessment of tissue localization and effector functions of gamma delta cells.

Main Results:

Related Experiment Videos

  • Gamma delta cells can expand via autoantigen recognition.
  • These cells are crucial for tissue damage and disease regulation.
  • Recent in vivo experiments confirm their significant role in autoimmune conditions.

Conclusions:

  • Gamma delta cells are significant mediators of autoimmune disease.
  • Their unique properties make them critical contributors to disease pathology.
  • Further research into gamma delta cells and their ligands is warranted.