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Biomedical silicone elastomers as carriers for controlled release

A G Andreopoulos1, M Plytaria

  • 1Department of Chemical Engineering, National Technical University of Athens, Greece.

Journal of Biomaterials Applications
|March 11, 1998
PubMed
Summary

Biomedical silicone elastomers show promise for drug delivery. Varying cross-linker ratios affect drug release rates, with membranes offering higher delivery than discs, depending on drug properties.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Pharmaceutical Sciences

Background:

  • Biomedical silicone elastomers possess unique properties suitable for controlled drug delivery applications.
  • Silicone-based materials are being explored as matrices for pharmaceutical agents.

Purpose of the Study:

  • To investigate the controlled release of drugs from silicone elastomer networks with varying cross-link densities.
  • To evaluate the influence of material structure and drug properties on drug delivery kinetics.

Main Methods:

  • Preparation of silicone elastomer networks with different cross-linker ratios.
  • Characterization of network properties using swelling experiments in toluene.
  • Loading of silicone matrices with salicylic acid and propranolol hydrochloride.

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  • In vitro drug release studies in distilled water.

    • Main Results:

    • Drug release kinetics were dependent on drug loading and cross-link density.
    • High loading of salicylic acid exhibited near zero-order release.
    • Delivery was diffusion-controlled up to a specific limit.
    • Silicone discs showed low drug concentrations due to hydrophobicity; thin membranes (0.1-0.2 mm) enhanced delivery rates significantly, influenced by drug hydrophilicity.

    Conclusions:

    • Silicone elastomers can be tailored for controlled drug release by adjusting cross-link density.
    • Membrane configuration and drug hydrophilicity are critical factors for achieving higher drug delivery rates.
    • Further research into silicone-based drug delivery systems is warranted.