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Related Experiment Videos

Simultaneous angle closure in twins

D Talluto1, M Feith, S Allee

  • 1Glaucoma Service, Northwestern University, Chicago, Illinois, USA.

Journal of Glaucoma
|March 11, 1998
PubMed
Summary

Identical twins simultaneously developed acute angle-closure glaucoma, suggesting genetic and environmental factors contribute to this eye condition. Early screening for potentially occludable angles is recommended, especially for twins.

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Area of Science:

  • Ophthalmology
  • Genetics
  • Public Health

Background:

  • Primary angle-closure glaucoma (PACG) is a significant cause of irreversible blindness worldwide.
  • Genetic predisposition and environmental triggers are implicated in PACG development.
  • Identical twins share nearly 100% of their genes, making them valuable for studying genetic influences on diseases.

Observation:

  • Two 73-year-old identical twin sisters presented concurrently with acute angle-closure glaucoma.
  • Both sisters experienced sudden vision loss and eye pain.
  • Clinical examination revealed significantly elevated intraocular pressure and signs of angle closure in one or both eyes for each twin.

Findings:

  • The simultaneous occurrence of acute angle-closure glaucoma in identical twins suggests a strong genetic component.
  • Environmental factors, such as physical trauma (a reported fist fight), may act as triggers in genetically susceptible individuals.
  • Both patients responded to medical management with anti-glaucoma medications and surgical intervention with bilateral laser iridotomies.

Implications:

  • This case highlights the importance of considering genetic factors in the etiology of angle-closure glaucoma.
  • Screening for potentially occludable angles is crucial in first-degree relatives of PACG patients, particularly in twin pairs.
  • Understanding the interplay between genetics and environment can lead to improved preventative strategies and earlier detection of glaucoma.

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