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Dilated Virchow-Robin spaces: MRI pathological study

M Adachi1, T Hosoya, T Haku

  • 1Department of Radiology, Yamagata University School of Medicine, Japan.

Neuroradiology
|March 11, 1998
PubMed
Summary
This summary is machine-generated.

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Dilated Virchow-Robin (V-R) spaces, often found in the anterior perforated substance and basal ganglia, were studied using histopathology and MRI. These spaces were consistently located in the lower basal ganglia, not near the brain surface.

Area of Science:

  • Neuroanatomy
  • Neuroimaging
  • Neuropathology

Background:

  • Virchow-Robin (V-R) spaces are perivascular spaces surrounding arteries and veins in the brain.
  • Dilated V-R spaces have been observed in various neurological conditions, but their typical location and characteristics require further elucidation.

Purpose of the Study:

  • To investigate the histopathological features of dilated Virchow-Robin (V-R) spaces in the anterior perforated substance and putamen.
  • To determine the characteristic location of dilated V-R spaces in the basal ganglia using Magnetic Resonance Imaging (MRI) in individuals without neurological deficits.

Main Methods:

  • Histopathological examination of two human brains, measuring the diameter of arteries within 54 dilated V-R spaces.
  • MRI analysis in 28 patients to identify dilated V-R spaces in the anterior perforated substance and basal ganglia, measuring their distance to the mamillary body.

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Main Results:

  • Histopathology revealed a mean arterial diameter of 39.0 +/- 36.0 microns within dilated V-R spaces, extending along the perforating artery from the pial membrane indentation.
  • MRI showed dilated V-R spaces located at a mean distance of 10.0 +/- 4.5 mm from the mamillary body, confined to the lower basal ganglia.

Conclusions:

  • Dilated Virchow-Robin spaces in the anterior perforated substance and basal ganglia exhibit characteristic histopathological and anatomical features.
  • MRI can reliably identify the typical location of these dilated V-R spaces within the lower basal ganglia, distinct from the brain surface.