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Thyreoglobulin and violent asphyxia

E Müller1, W G Franke, R Koch

  • 1Institut für Rechtsmedizin, Technische Universität Dresden, Universitätsklinikum Carl Gustav Carus, Germany.

Forensic Science International
|March 11, 1998
PubMed
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Elevated thyreoglobulin (TG) levels indicate a vital reaction in obstructive asphyxia. These TG concentrations help distinguish deaths from hanging, strangulation, and throttling from other causes.

Area of Science:

  • Forensic Pathology
  • Biochemistry

Background:

  • Thyreoglobulin (TG) is a protein produced by the thyroid gland.
  • Elevated TG levels have been observed in various physiological and pathological conditions.

Purpose of the Study:

  • To investigate the diagnostic utility of thyreoglobulin (TG) concentrations in determining the cause of death, specifically in cases of obstructive asphyxia.
  • To differentiate between deaths caused by hanging, strangulation by ligature, manual strangulation, and other causes of sudden death.

Main Methods:

  • Measurement of thyreoglobulin (TG) concentrations in post-mortem samples.
  • Comparison of TG levels across different groups: hanging, strangulation by ligature, manual strangulation, sudden violent deaths, and living healthy individuals.
  • Statistical analysis to determine significant differences in TG levels.

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Main Results:

  • Mean TG values were significantly higher in cases of manual strangulation (561.6 +/- 173.9 ng/ml), strangulation by ligature (193.1 +/- 173.3 ng/ml), and hanging (149.9 +/- 202.3 ng/ml) compared to sudden violent deaths (23.3 +/- 27.6 ng/ml) and living individuals (17.3 +/- 16.1 ng/ml).
  • Statistically significant differences (adjusted P < 0.001) were found between manual strangulation and strangulation by ligature, and between manual strangulation and hanging.
  • High TG values were observed in cases of obstructive asphyxia.

Conclusions:

  • Elevated thyreoglobulin (TG) concentrations can be considered a vital reaction in cases of obstructive asphyxia.
  • TG measurement may serve as a valuable biomarker in forensic investigations to identify deaths resulting from specific forms of asphyxia.