Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[The relationship between a decrease in fat mass and serum levels of TNF-alpha in patients with chronic obstructive

C Yamamoto1, T Yoneda, M Yoshikawa

  • 1Second Department of Internal Medicine, Nara Medical University, Japan.

Nihon Kyobu Shikkan Gakkai Zasshi
|March 11, 1998
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Creamy clues to monogenic hypertriglyceridaemia.

Hong Kong medical journal = Xianggang yi xue za zhi·2026
Same author

Glucocorticoid-prescribing trends in congenital adrenal hyperplasia, 2017 to 2023.

Endocrine connections·2026
Same author

"Primer shot" fractionation with an early treatment break is theoretically superior to consecutive weekday fractionation schemes for early-stage non-small cell lung cancer.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2023
Same author

Expression and purification of antimicrobial peptide AP2 using SUMO fusion partner technology in Escherichia coli.

Letters in applied microbiology·2018
Same author

The Plastid Terminal Oxidase is a Key Factor Balancing the Redox State of Thylakoid Membrane.

The Enzymes·2016
Same author

Association between age at first sexual intercourse and knowledge, attitudes and practices regarding reproductive health and unplanned pregnancy: a cross-sectional study.

Public health·2016

Tumor necrosis factor-alpha (TNF-alpha) is linked to malnutrition in chronic obstructive pulmonary disease (COPD) patients. Elevated TNF-alpha levels correlate with reduced fat mass, suggesting a role in COPD-related malnutrition.

Area of Science:

  • Biochemistry
  • Immunology
  • Pulmonology

Context:

  • Chronic obstructive pulmonary disease (COPD) is often associated with malnutrition.
  • Tumor necrosis factor-alpha (TNF-alpha) is a pro-inflammatory cytokine implicated in various disease states.

Purpose:

  • To investigate the relationship between malnutrition and TNF-alpha levels in patients with stable COPD.
  • To determine if TNF-alpha is associated with body composition changes, specifically fat mass and lean mass, in COPD patients.

Summary:

  • Serum TNF-alpha levels were significantly higher in COPD patients with lower ideal body weight (%IBW < 80) compared to those with higher %IBW and healthy controls.
  • Serum TNF-alpha levels showed a significant negative correlation with fat mass (r = -0.67, p < 0.001) in COPD patients.

Related Experiment Videos

  • No association was found between lean mass and serum TNF-alpha levels.

    • Impact:

    • These findings suggest that TNF-alpha plays a role in the malnutrition observed in COPD patients.
    • Elevated TNF-alpha may contribute to the loss of fat mass, a component of cachexia, in COPD.
    • This research highlights a potential therapeutic target for managing malnutrition in COPD.