Related Experiment Video
Updated: Jul 26, 2026

Assaying β-amyloid Toxicity using a Transgenic C. elegans Model
Published on: October 10, 2010
Caffeine, but not time of day, increases whole-arm physiological tremor in non-smoking moderate users
L S Miller1, T W Lombardo, S C Fowler
1The University of Georgia Department of Psychology, Athens 30602-3013, USA. LSMILLER@EGON.PSY.UGA.EDU
Abstract:
1. Consumptive levels of caffeine significantly increased whole-arm physiological tremor in young adult males at 3 but not 1 mg caffeine/kg bodyweight. 2. Physiological tremor was not affected by time of day (TOD) or the interaction of caffeine and TOD. 3. Findings suggest that ingestion of a single oral dose of caffeine at typical consumptive levels results in measurable changes in physiological functioning and that whole-arm physiological tremor is a sensitive measure of physiological change due to drug effects. 4. However, the results suggest that whole-arm physiological tremor may not detect reliably TOD changes in functioning.
Related Concept Videos
Drugs Acting on Autonomic Ganglia: Stimulants
Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating sympathetic or...
CNS Depressants: Alcohol and Nicotine
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
Anxiolytic Drugs: Benzodiazepines and Buspirone
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Stimulants
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...

