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Unidirectional transfer of D-xylose across the rat placenta
F Staud1, Z Fendrich, R Karlícek
1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Charles University, Heyrovského, Czech Republic. fstaud@pharm.kyoto-u.ac.jp
Abstract:
1. The transplacental transfer of D-xylose was investigated in the present study. 2. Umbilical perfusion of the rat term placenta was used to study materno-foetal (M-F) and foetomaternal (F-M) transfer of this compound. 3. D-Xylose was found to cross the rat term placenta very quickly in the M-F direction, with subsequent accumulation in the foetal compartment (the F-M ratio being 2.23 at the end of the experiments). In contrast, no transfer in the F-M direction was observed. 4. A possible facilitation of the transplacental transfer of D-xylose from the mother to foetus in rats is suggested.