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Related Experiment Videos

Microvessel density in brain tumors

M Assimakopoulou1, G Sotiropoulou-Bonikou, T Maraziotis

  • 1University of Patras School of Medicine, Department of Anatomy, Greece.

Anticancer Research
|March 12, 1998
PubMed
Summary

Microvessel count (MVC) in brain tumors correlates with histological grade, with malignant astrocytomas showing higher vascularity. This finding supports microvessel density as a key feature for brain tumor classification and potential anti-angiogenesis therapy monitoring.

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Area of Science:

  • Neuropathology
  • Oncology
  • Vascular Biology

Background:

  • Microvessel count (MVC) is an indicator of tumor angiogenesis.
  • Understanding vascularity in different brain tumor types is crucial for diagnosis and treatment.

Purpose of the Study:

  • To determine and correlate microvessel count (MVC) with histological grade in various brain tumors.
  • To assess the potential of MVC as a diagnostic and prognostic marker.

Main Methods:

  • Immunohistochemical staining for factor VIII-related antigen in formalin-fixed paraffin-embedded tumor tissues from 165 patients.
  • Quantification of microvessel density (MVD) by counting microvessels in areas of highest vascularity at X200 magnification.
  • Correlation of MVC with tumor type, histological grade, patient age, and sex.

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Main Results:

  • Malignant astrocytic tumors (grade III and IV) exhibited significantly higher MVC compared to lower-grade astrocytomas and meningiomas.
  • Cerebellar astrocytomas (grade I/II) showed higher vascularity than supratentorial astrocytomas (grade I/II).
  • MVC was independent of patient age and sex.

Conclusions:

  • Microvessel density is a significant morphologic feature in brain tumor classification.
  • Increased MVC in higher-grade astrocytomas highlights its role in tumor progression.
  • MVC determination may aid in planning and monitoring anti-angiogenesis therapies for brain tumors.