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A case of chronic myelomonocytic leukemia with isochromosome 14q
L Flaherty1, A Jarvis, M Harris
1Department of Cytogenetics, Royal Alexandra Hospital, Westmead, New South Wales, Australia.
Cancer Genetics and Cytogenetics
|March 12, 1998
Abstract:
A 72-year-old man with increased monocytes and eosinophils in the bone marrow was found to have an isochromosome, i(14q), as the sole abnormality on bone-marrow cytogenetics. Follow-up over 12 months with repeat cytogenetic testing of bone marrow specimens on three further occasions showed an additional abnormality consisting of an apparently balanced translocation, t(6;21)(p21.1; q22). This abnormality, together with other features, indicated disease progression. A review of seven reported cases of i(14q) revealed limited follow-up information.