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Microbial complexes in subgingival plaque

S S Socransky1, A D Haffajee, M A Cugini

  • 1Department of Periodontology, Forsyth Dental Center, Boston, MA 02115, USA.

Journal of Clinical Periodontology
|March 12, 1998
PubMed
Summary
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Subgingival plaque harbors bacterial complexes, with five major groups identified. One complex, including Bacteroides forsythus, Porphyromonas gingivalis, and Treponema denticola, strongly correlates with periodontal disease severity.

Area of Science:

  • Microbiology
  • Periodontology
  • Bioinformatics

Background:

  • Bacterial species form complex communities within subgingival plaque.
  • Understanding these complex structures is crucial for diagnosing and treating periodontal diseases.

Purpose of the Study:

  • To define subgingival bacterial communities using advanced analytical techniques.
  • To identify distinct bacterial complexes within subgingival plaque samples.

Main Methods:

  • Analysis of 13,261 subgingival plaque samples from 185 subjects (with and without periodontitis).
  • Utilized whole genomic DNA probes and checkerboard DNA-DNA hybridization to identify 40 subgingival taxa.
  • Employed phi coefficients, unweighted average linkage clustering, principal components analysis, and correspondence analysis.

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Main Results:

  • Consistently identified 5 major bacterial complexes across analytical methods.
  • Complex 1: Bacteroides forsythus, Porphyromonas gingivalis, Treponema denticola.
  • Complex 1 showed a strong association with periodontal disease indicators like pocket depth and bleeding on probing.

Conclusions:

  • Subgingival plaque harbors distinct bacterial complexes.
  • The identified complexes provide a framework for understanding oral microbial ecology.
  • Complex 1's association with periodontal disease highlights its pathogenic potential.