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Related Experiment Videos

Positron emission tomography studies in movement disorders

D J Brooks1

  • 1MRC Cyclotron Unit, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom.

Neurosurgery Clinics of North America
|April 29, 1998
PubMed
Summary

Positron emission tomography (PET) scanning reveals brain changes in movement disorders. This review highlights PET

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Neurology

Background:

  • Movement disorders like Parkinson's disease and essential tremor involve complex changes in brain function.
  • Positron emission tomography (PET) is a powerful neuroimaging technique for assessing brain metabolism and receptor binding.
  • Understanding these changes is crucial for developing and evaluating therapeutic interventions.

Purpose of the Study:

  • To review the application of Positron emission tomography (PET) in movement disorders.
  • To highlight the use of PET in evaluating the effects of therapeutic interventions, specifically stereotactic surgery and transplantation.
  • To examine how PET assesses changes in brain function in Parkinson's disease and tremor patients.

Main Methods:

  • Utilizing Positron emission tomography (PET) for quantitative examination of brain function.
  • Assessing regional cerebral blood flow, glucose metabolism, and oxygen metabolism.
  • Analyzing brain pharmacology and receptor binding patterns.

Main Results:

  • PET enables sensitive detection and characterization of regional brain alterations in movement disorders.
  • The technique allows for quantitative assessment of metabolic and pharmacological changes.
  • PET can effectively monitor the impact of surgical and transplantation therapies on brain function.

Conclusions:

  • Positron emission tomography (PET) is an invaluable tool for studying the pathophysiology of movement disorders.
  • PET imaging provides critical insights into the efficacy of advanced therapeutic strategies.
  • Further research utilizing PET will advance our understanding and treatment of Parkinson's disease and tremor.

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