Height and weight in cystic fibrosis: a cross sectional study. UK Cystic Fibrosis Survey Management Committee

S Morison1, J A Dodge, T J Cole

  • 1Department of Child Health, Queen's University of Belfast.

Insights

UK patients with cystic fibrosis show improved height and weight in childhood but still experience deficits post-puberty. These findings suggest ongoing challenges in growth maintenance for individuals with cystic fibrosis.

Area of Science:

  • Pediatric Endocrinology
  • Pulmonology
  • Clinical Nutrition

Background:

  • Cystic fibrosis (CF) is a genetic disorder affecting multiple organs, notably the lungs and digestive system.
  • Growth abnormalities, including reduced height and weight, are common complications in CF patients.
  • Previous studies indicated significant growth deficits in CF populations.

Purpose of the Study:

  • To present cross-sectional data on anthropometric measurements (height, weight, BMI) in UK patients with cystic fibrosis.
  • To assess growth patterns in CF patients across different age groups.
  • To identify potential factors influencing growth maintenance in CF.

Main Methods:

  • Cross-sectional study design.
  • Data collection on height, weight, and body mass index (BMI).
  • Analysis of anthropometric data in UK cystic fibrosis patients.

Main Results:

  • During the first decade of life, CF patients' height and weight were approximately 0.5 standard deviations below the general population.
  • This represents an improvement compared to historical data.
  • Substantial deficits in postpubertal stature and weight were observed in the CF cohort.

Conclusions:

  • While childhood growth has improved in CF patients, significant challenges remain in achieving optimal growth post-puberty.
  • Treatment strategies may need further optimization to address persistent growth deficits.
  • Continued monitoring of anthropometric parameters is crucial for managing cystic fibrosis care.

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