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Disopyramide improves the balance between myocardial oxygen supply and demand in patients with hypertrophic

K Niki1, M Sugawara, R Asano

  • 1Heart Institute of Japan, Tokyo Women's Medical College, Japan.

Heart and Vessels
|January 1, 1997
PubMed

Insights

Disopyramide effectively improves the oxygen supply-demand balance in patients with hypertrophic obstructive cardiomyopathy (HOCM). This cardiac medication reduces myocardial oxygen demand without altering oxygen supply, benefiting HOCM patients.

Area of Science:

  • Cardiology
  • Cardiovascular Physiology

Background:

  • Hypertrophic obstructive cardiomyopathy (HOCM) is characterized by impaired myocardial oxygen supply-demand balance.
  • Understanding interventions that can improve this balance is crucial for managing HOCM patients.

Purpose of the Study:

  • To evaluate the effects of disopyramide on myocardial oxygen supply and demand in patients with HOCM.
  • To determine if disopyramide can improve the oxygen supply-demand balance in this patient population.

Main Methods:

  • Assessed myocardial oxygen supply by measuring coronary flow velocity.
  • Evaluated myocardial oxygen demand using pressure-volume area (PVA).
  • Measured peak left ventricular pressure and left ventricular external work before and after disopyramide administration.

Main Results:

  • Disopyramide did not significantly alter the time velocity integral of coronary flow (myocardial oxygen supply).
  • Significant reductions were observed in peak left ventricular pressure and left ventricular external work (myocardial oxygen demand) post-disopyramide.
  • P-values indicate statistical significance (P < 0.001) for the observed decreases.

Conclusions:

  • Disopyramide administration leads to a significant decrease in myocardial oxygen demand in HOCM patients.
  • Theoretical analysis suggests disopyramide improves the myocardial oxygen supply-demand balance in HOCM.
  • Disopyramide represents a potential therapeutic option for improving cardiac energetics in HOCM.

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