Meningioma with perivascular pseudorosettes: a morphological entity distinct from papillary meningioma?

Related Experiment Video

Updated: Oct 30, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
08:57

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

J Pimentel1, L Albuquerque, L Tavora

  • 1Department of Neurology, Hospital de Santa Maria, Lisboa, Portugal.

Clinical Neuropathology
|March 13, 1998
PubMed

Insights

Papillary meningiomas may be misidentified; this case highlights tumors with perivascular pseudorosettes that mimic papillary variants. Morphological distinction is crucial despite similar clinical behavior.

Area of Science:

  • Neuropathology
  • Oncology

Background:

  • Papillary meningioma is a recognized variant of meningioma.
  • Previous reports often lack classical papillary structures.

Observation:

  • A case of a 79-year-old man with a convexity meningioma is presented.
  • The tumor recurred 36 months after complete surgical removal.
  • Tumor cells mimicked astrocytic cells and formed perivascular pseudorosettes.

Findings:

  • Literature review suggests potential morphological misinterpretation of papillary meningiomas.
  • Papillary variants and those with perivascular pseudorosettes share similar, generally non-malignant behavior.
  • Strict morphological differentiation between these variants is recommended.

Implications:

  • Accurate histopathological classification of meningiomas is essential for understanding tumor behavior.
  • Distinguishing between papillary meningioma and tumors with perivascular pseudorosettes may refine prognostication.
  • Further research is needed to clarify the distinct biological and clinical characteristics of these variants.

Related Concept Videos

Cranial and Spinal Meninges01:19

Cranial and Spinal Meninges

The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...