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Related Experiment Videos

Functional redundancy and gustatory development in bdnf null mutant mice

D Cooper1, B Oakley

  • 1Department of Biology, University of Michigan, Ann Arbor 48109-1048, USA.

Brain Research. Developmental Brain Research
|March 13, 1998
PubMed
Summary
This summary is machine-generated.

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Brain-derived neurotrophic factor (BDNF) is crucial for taste neuron survival. In its absence, redundant factors in local taste bud epithelium likely rescue remaining neurons, enabling taste bud formation.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Sensory Biology

Background:

  • Taste bud development relies on taste neuron survival.
  • Brain-derived neurotrophic factor (BDNF) plays a key role in taste neuron development.
  • Null mutations in BDNF lead to significant taste neuron death and impaired taste bud formation.

Purpose of the Study:

  • To identify the source of a rescue factor that compensates for the absence of BDNF in taste neuron survival.
  • To investigate the role of local gustatory epithelium in supporting surviving taste neurons.
  • To understand the mechanisms of functional redundancy in neurotrophic support for sensory neurons.

Main Methods:

  • Analysis of taste bud formation in BDNF null mutant mice.
  • Comparison of taste bud abundance across different gustatory papillae (nasopalate, foliate, vallate).

Related Experiment Videos

  • Assessment of taste neuron survival and innervation patterns.

    • Main Results:

    • BDNF null mutation caused extensive embryonic taste neuron death and failed taste bud formation.
    • A variable number of taste neurons survived due to functional redundancy.
    • The proportion of surviving taste buds varied independently across different papillae, suggesting localized rescue.
    • This variation ruled out system-wide or ganglion-level rescue factors.

    Conclusions:

    • Surviving BDNF-deprived taste neurons are likely rescued by redundant neurotrophic factors present in the local gustatory epithelium.
    • This finding challenges the traditional view that target tissues supply only a single neurotrophic factor for sensory neuron survival.
    • Gustatory papillae exhibit independent variation in residual innervation, indicating localized neurotrophic support mechanisms.